nmda receptor antagonist 2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40999	NMDA receptor antagonist 2
	NMDA receptor antagonist 2 is a highly potent and orally active NR2B subtype-selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. It exhibits remarkable binding affinities, with an IC50 of 1.0 nM and a Ki va...
T12110	MRZ 2-514	8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one	NMDAR
	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.		NMDAR
T22674	Co 101244 hydrochloride	4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride	NMDAR
	Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) is an NR2B-containing NMDA receptor antagonist.		NMDAR
T8459	DNQX disodium salt	DNQX Disodium	NMDAR , iGluR
	DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor		NMDAR , iGluR
T67946	EP2 receptor antagonist-2		Prostaglandin Receptor
	EP2 receptor antagonist-2 (CID891729) is a compound that not only serves as an antagonist to the EP2 receptor, blocking its activation by PGE2, but also reduces lactate dehydrogenase (LDH) release triggered by N-methyl-D...		Prostaglandin Receptor
T7304	DNQX	FG 9041	GluR , iGluR
	DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)		GluR , iGluR
T16564	PPADS tetrasodium		P2X Receptor , Na+/Ca2+ Exchanger
	PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma in...		P2X Receptor , Na+/Ca2+ Exchanger
T4752	1-Aminocyclopropane-1-carboxylic acid	1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite , NMDAR
	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...		Endogenous Metabolite , NMDAR
T60330	Metapramine
	Metapramine (19560 RP) is a tricyclic antidepressant[1]. Metapramine inhibits norepinephrine reuptake without affecting the reuptake of serotonin or dopamine [1] [2] [3]. Metapramine is a low-affinity antagonist of the N...
T10191L	7-Chlorokynurenic acid	7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA	GluR , NMDAR
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake...		GluR , NMDAR
T4705	Aminoadipic acid	DL-2-Aminoadipic acid	Others , Endogenous Metabolite
	Aminoadipic acid (DL-2-Aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine...		Others , Endogenous Metabolite
T73713	Flupirtine-d4 hydrochloride
	Flupirtine-d4 (D 9998-d4) hydrochloride, the deuterium-labeled version of Flupirtine (D 9998) hydrochloride, is a selective neuronal potassium channel opener with additional NMDA receptor antagonist properties [1] [2].
T60578	Procyclidine
	Procyclidine (Tricyclamol; (±)-Procyclidine) is an anticholinergic agent which is a muscarinic receptor antagonist as well as an N-methyl-D-aspartate ( NMDA ) antagonist. Procyclidine can be used in studies of Parkinson'...
T27269	Ensaculin HCl	KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl
	Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and...
T22048	Bis(7)-Tacrine
	Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine with a potential to treat Alzheimer's disease. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA...
T79571	AChE/Aβ-IN-2
	AChE/Aβ-IN-2 (compound 33) is a powerful, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 135 nM. It also functions as an NMDA receptor antagonist (GluN1-1b/GluN2B subunit combination) with an IC50 of...
T70063	GYKI 52466 HCl
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i...